Newly diagnosed with multiple sclerosis? Talk to your doctor about your whole health

(BPT) – If you’ve been diagnosed with multiple sclerosis (MS), it’s common to feel overwhelmed and unsure of what to do next.1 With an ever-changing disease like MS, everyone’s personal experience is different, so it’s important to be open and honest with your doctor about your MS symptoms and how it may affect your day-to-day life and goals.2 This will help you and your doctor create a personalized plan that addresses your whole health.Need advice on where to start? Here are three important topics to discuss with your doctor about how MS can affect your daily life.Keep mental and emotional health top-of-mind Following an MS diagnosis, focusing on your physical health is critical, but it’s important to also take care of your emotional well-being for overall wellness.3 Everyday life can be stressful enough, but for people living with MS, this can be compounded by the unpredictability of the disease.3 In addition to stress, people living with MS often experience other emotional changes, such as depression, anxiety and irritability.3 In fact, people with MS may be 2-3 times more likely to experience clinical depression than the general population.4 Nurse practitioner Stephanie Agrella, PhD, APRN, B.C., Director of Clinical Services, Multiple Sclerosis Clinic at Central Texas Neurology, shares her experience helping newly diagnosed MS patients over the years, noting, “Mental health is so important. I always start visits with my patients by asking how they’re feeling emotionally. Many of my patients have benefited from talking with a counselor or finding a support group.”If you’re experiencing emotional changes like grief, anxiety or depression, consider seeking support through counseling, joining self-help groups and building a supportive environment, or seeing a mental health professional.3 There are a number of resources available to help you find support, including on the National Multiple Sclerosis Society website.Understand that MS can impact your intimate relationships Personal relationships and intimacy are crucial to living a full life, and that’s no different for people living with MS.5 However, MS can present challenges when it comes to intimate relationships, and changes in your sexual health may interfere with your quality of life.6 If you’re newly diagnosed with MS and experiencing sexual problems, you’re not alone. Sexual dysfunction is very common, yet patients and doctors are often hesitant to bring up this topic.2,6 Discuss strategies with your doctor that may help address changes in your sexual health, including treatment.“Some of my patients ask me if MS can impact their libido, and the answer is ‘yes,’” said Agrella. “This can happen for a few reasons, so be sure to have an open conversation with your doctor to determine if it’s your MS or something else causing changes in your sexual health. My hope is that each patient finds a doctor they feel comfortable with to discuss more intimate topics, like sexual health, that can really impact their day-to-day life.” It may be helpful to keep track of your symptoms in a journal so you can recognize patterns and have a record to reference when discussing with your doctor.5 Talk about what’s next in your life plansMost people are diagnosed with MS between ages 20 to 50.7 With a higher prevalence of MS in women — who are three times more likely to be diagnosed with MS than men — this can cause many patients to wonder how MS may impact their life plans like starting a family.7,8“Family planning is something many of my patients ask about, often at our first visit,” says Agrella. “It’s an important factor that helps shape a personalized treatment plan for them, since some treatments offer patients more flexibility.” There are no disease-modifying therapies approved for use during pregnancy.8 Keep your doctor updated on any plans to start a family, so you can work together to tailor your treatment plan accordingly.Discuss available treatment options In the past five years alone, five new MS treatments were approved in the U.S., including the most recent FDA-approved option, PONVORY®, a once-daily oral treatment for adults with relapsing MS.9,10 In a two-year clinical study, PONVORY® was superior at reducing the number of relapses and lesions compared to a proven oral therapy,* and nearly 90% of people taking PONVORY® showed no disability progression over two years.10† With any medication, it’s important to understand the potential side effects. The most common side effects for PONVORY® are upper respiratory tract infections, elevated liver enzymes (abnormal liver tests) and high blood pressure.10‡If you are considering pregnancy, PONVORY® may also be an option to discuss with your doctor, as it leaves the body naturally in about one week after pausing treatment with no elimination procedure required.10§ Use effective contraception during and for up to one week after stopping PONVORY®.10¶“Especially for people who are newly diagnosed, it’s important to tell your doctor how MS is impacting your daily life, including emotional well-being and sexual health, as well as any plans to start a family,” notes Agrella. “These types of honest conversations help inform shared decision-making, which is key to a personalized treatment plan. Be sure to ask your doctor about the variety of available treatment options that may be right for you.”PONVORY® is not indicated for emotional changes such as depression, anxiety, and irritability or sexual changes such as sexual dysfunction. *PONVORY® reduced the average number of new gadolinium-enhancing (GdE) T1 and new or enlarging T2 lesions.†There was no statistically significant difference in the percentages of people experiencing disability progression between PONVORY® and its comparator. Disability progression was determined with predefined increases in Expanded Disability Status Scale (EDSS) scores, which were confirmed after 3 months over the course of the ~2-year study. 3-month disability progression was observed in 10.8% of people taking PONVORY® vs 13.2% of people taking a proven oral therapy.‡While these are the most common side effects, there are other serious potential side effects of PONVORY®.§When PONVORY® is stopped, symptoms of multiple sclerosis may return and become worse compared with before or during treatment. Always talk to your healthcare professional before you stop taking PONVORY® for any reason. Tell your healthcare professional if you have worsening symptoms of multiple sclerosis after stopping PONVORY®.¶PONVORY® may be harmful to unborn babies. Patients should talk to a healthcare provider if they are pregnant or plan to become pregnant.IMPORTANT SAFETY INFORMATIONWHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT PONVORY®?PONVORY® may cause serious side effects, including:Infections — PONVORY® can increase your risk of serious infections that can be life-threatening and cause death. PONVORY® lowers the number of white blood cells (lymphocytes) in your blood. This will usually go back to normal within 1 to 2 weeks of stopping treatment. Your healthcare provider should review a recent blood test of your white blood cells before you start taking PONVORY®. Call your healthcare provider right away if you have any of these symptoms of an infection during treatment and for 1 to 2 weeks after your last dose of PONVORY®:fevertirednessbody acheschillsnauseavomitingheadache with fever, neck stiffness, sensitivity to light, nausea, or confusion (these may be symptoms of meningitis, an infection of the lining around your brain and spine)Your healthcare provider may delay starting or may stop your PONVORY® treatment if you have an infection.Slow heart rate (bradycardia or bradyarrhythmia) when you start taking PONVORY®. PONVORY® can cause your heart rate to slow down, especially after you take your first dose. You should have a test to check the electrical activity of your heart called an electrocardiogram (ECG) before you take your first dose.Only Start your treatment with PONVORY® using the Starter Pack. You must use the PONVORY® Starter Pack by slowly increasing the dose over a 14-day period to help reduce the effect of slowing of your heart rate. It is important to follow the recommended dosing instructions.Call your healthcare provider if you experience the following symptoms of slow heart rate:dizzinessshortness of breathlightheadednessconfusionfeeling like your heart is beating slowly or skipping beatschest paintirednessDo not take PONVORY® if you:have had a heart attack, chest pain called unstable angina, stroke or mini-stroke (transient ischemic attack or TIA), or certain types of heart failure in the last 6 months.have certain types of heart block or irregular or abnormal heartbeat (arrhythmia) unless you have a pacemaker.Talk to your healthcare provider if you have any of these conditions, or do not know if you have any of these conditions.Before you take PONVORY®, tell your healthcare provider about all your medical conditions, including if you:have a fever or infection, or you are unable to fight infections due to a disease or taking medicines that lower your immune system.have had chicken pox or have received the vaccine for chicken pox. Your healthcare provider may do a blood test for chicken pox virus. You may need to get the full course of vaccine for chicken pox and then wait 1 month before you start taking PONVORY®.have slow heart rate.have an irregular or abnormal heartbeat (arrhythmia).have a history of stroke.have heart problems, including a heart attack or chest pain.have high blood pressure.have breathing problems, including during your sleep.have liver problems.have or now have a type of skin cancer called basal cell carcinoma (BCC), melanoma, or squamous cell carcinoma.have eye problems, especially an inflammation of the eye called uveitis.have diabetes.are pregnant or plan to become pregnant. PONVORY® may harm your unborn baby. Talk with your healthcare provider if you are pregnant or plan to become pregnant. If you are a woman who can become pregnant, you should use effective birth control during your treatment with PONVORY® and for 1 week after you stop taking PONVORY®. Talk to your healthcare provider about what method of birth control is right for you during this time. Tell your healthcare provider right away if you do become pregnant while taking PONVORY® or within 1 week after you stop taking PONVORY®.are breastfeeding or plan to breastfeed. It is not known if PONVORY® passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take PONVORY®.Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Using PONVORY® and other medicines together may affect each other causing serious side effects.Especially tell your healthcare provider if you take or have taken: Medicines to control your heart rhythm (antiarrhythmics), or blood pressure (antihypertensives), or heart-beat (such as calcium channel blockers or beta-blockers); medicines that affect your immune system, such as alemtuzumab; and medicines such as rifampin, phenytoin, or carbamazepine.You should not receive live vaccines during treatment with PONVORY®, for at least 1 week before taking and for 1 month after you stop taking PONVORY®. If you receive a live vaccine, you may get the infection the vaccine was meant to prevent. Vaccines may not work as well when given during treatment with PONVORY®.Talk with your healthcare provider if you are not sure if you take any of these medicines.HOW SHOULD I TAKE PONVORY®?Take PONVORY® exactly as your healthcare provider tells you to take it.Take PONVORY® 1 time each day.Swallow PONVORY® tablets whole.Take PONVORY® with or without food.Do not stop taking PONVORY® without talking with your healthcare provider first.Do not skip a dose.Start taking PONVORY® with a 14-day starter pack.If you miss taking 1, 2, or 3 tablets in a row of PONVORY® in the 14-day starter pack, continue treatment by taking the first dose you missed. Take 1 tablet as soon as you remember. Then, take 1 tablet a day to continue with the starter pack dose as planned.If you miss taking 1, 2, or 3 tablets in a row of PONVORY® while taking the 20 mg maintenance dose, continue treatment with the 20 mg maintenance dose.If you miss taking 4 or more tablets in a row of PONVORY®, while taking the 14-day starter pack or the 20 mg maintenance dose, you need to restart treatment with a new 14-day starter pack. Call your healthcare provider if you miss 4 or more doses of PONVORY®. Do not restart PONVORY® after stopping it for 4 or more days in a row without talking to your healthcare provider. If you have certain heart conditions, you may need to be monitored by your healthcare provider for at least 4 hours when you take your next dose.What are the possible side effects of PONVORY®?PONVORY® may cause serious side effects, including:breathing problems. Some people who take PONVORY® have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.liver problems. PONVORY® may cause liver problems. Your healthcare provider should do blood tests to check your liver before you start taking PONVORY®. Call your healthcare provider right away if you have any of the following symptoms of liver problems:unexplained nauseavomitingstomach (abdominal) paintirednessloss of appetiteyellowing of the whites of your eyes or skindark urineincreased blood pressure. Your healthcare provider should check your blood pressure during treatment.types of skin cancer called basal cell carcinoma (BCC), melanoma, and squamous cell carcinoma. Certain types of skin cancer have happened with drugs in the same class. Tell your healthcare provider if you have any changes in the appearance of your skin, including changes in a mole, a new darkened area on your skin, a sore that does not heal, or growths on your skin, such as a bump that may be shiny, pearly white, skin-colored, or pink. Your doctor should check your skin for any changes during treatment with PONVORY®. Limit the amount of time you spend in sunlight and ultraviolet (UV) light. Wear protective clothing and use a sunscreen with a high sun protection factor.a problem with your vision called macular edema. Tell your healthcare provider about any changes in your vision. Your healthcare provider should test your vision before you start taking PONVORY® and any time you notice vision changes during treatment with PONVORY®. Your risk of macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis.Call your healthcare provider right away if you have any of the following symptoms:blurriness or shadows in the center of your visiona blind spot in the center of your visionsensitivity to lightunusually colored (tinted) visionswelling and narrowing of the blood vessels in your brain. A condition called Posterior Reversible Encephalopathy Syndrome (PRES) has happened with drugs in the same class. Symptoms of PRES usually get better when you stop taking PONVORY®. However, if left untreated, it may lead to a stroke. Call your healthcare provider right away if you have any of the following symptoms:sudden severe headachesudden confusionsudden loss of vision or other changes in visionseizuresevere worsening of multiple sclerosis (MS) after stopping PONVORY®.When PONVORY® is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking PONVORY® for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping PONVORY®.The most common side effects of PONVORY® include:upper respiratory tract infectionselevated liver enzymes (abnormal liver tests)high blood pressure (hypertension)These are not all the possible side effects of PONVORY®. For more information, ask your healthcare provider or pharmacist. See “What is the most important information I should know about PONVORY®?”Tell your doctor if you have any side effect that bothers you or that does not go away.Call your doctor for medical advice about side effects. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Janssen Pharmaceuticals, Inc., at 1-800-JANSSEN (1-800-526-7736).Please see full Prescribing Information and Medication Guide.Trademarks are those of their respective owners.cp-214883v2This article is sponsored by Janssen Pharmaceuticals, Inc.1 National Multiple Sclerosis Society. Newly Diagnosed. National Multiple Sclerosis Society website. Accessed April 18, 2022. https://www.nationalmssociety.org/Symptoms-Diagnosis/Newly-Diagnosed2 National Multiple Sclerosis Society. MS Signs & Symptoms. National Multiple Sclerosis Society website. Accessed March 1, 2022. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms3 National Multiple Sclerosis Society. MS Emotional Changes. National Multiple Sclerosis Society website. Accessed March 1, 2022. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Emotional-Changes4 Patten SB, Marrie RA, Carta MG. Depression in multiple sclerosis. Int Rev Psychiatry. 2017;29(5):463-472. doi:10.1080/09540261.2017.13225555 National Multiple Sclerosis Society. Intimacy and Sexuality in MS. National Multiple Sclerosis Society website. Accessed March 1, 2022. https://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Brochure-Intimacy-and-Sexuality.pdf6 National Multiple Sclerosis Society. Sexual Problems. National Multiple Sclerosis Society website. Accessed March 1, 2022. https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Sexual-Dysfunction7 National Multiple Sclerosis Society. Who Gets MS. National Multiple Sclerosis Society website. Accessed March 1, 2022. https://www.nationalmssociety.org/What-is-MS/Who-Gets-MS8 National Multiple Sclerosis Society. Pregnancy and Reproductive Issues. National Multiple Sclerosis Society website. Accessed March 14, 2022. https://www.nationalmssociety.org/Living-Well-With-MS/Diet-Exercise-Healthy-Behaviors/Womens-Health/Pregnancy9 National Multiple Sclerosis Society. Disease-Modifying Therapies for MS. National Multiple Sclerosis Society website. Accessed February 28, 2022. https://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Brochure-The-MS-Disease-Modifying-Medications.pdf10 PONVORY® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc. April 2021.